Ram Research Directory

S. Anne Boettger

Education

• Ph.D. Biology - University of Alabama at Birmingham
• B.Sc. Hons Zoology (Marine and Fisheries) - Aberdeen University, UK
• Prediploma Biology - Osnabrueck University, Germany

Research Interests

invertebrate modelsenvironmental impactsbiological factorsphysical factorsculture techniquessea urchins cultureproliferative human diseases

Opportunities

Work Study Positions Available: No

Grant Funded Positions Available: No

Course-Credit Research Opportunities Available: No

Volunteer Research Positions Available: No

Biography

Dr. Boettger examines environmental impacts on invertebrate models in two different systems, edible sea urchins and clams. Her research examines the impact of biological (diet) and physical (light) factors on culture techniques to promote sea urchins culture. This section of her research is looking to improve culture of the green sea urchin Strongylocentrotus droebachiensis. Green sea urchins are of substantial economic value in Japan and sushi houses around the country and have subsequently been overfished and populations have been decimated. The other aspect of her research uses the soft-shell clam Mya arenaria as a model for proliferative human diseases and onset and development of these diseases. The soft-shell clam is afflicted with a neoplasia that displays morphological similarities to human Burkitt’s lymphoma and yet is similar on a molecular level to colon carcinoma and glioblastoma. Research opportunities with Dr. Boettger will incorporate techniques from culture techniques, physiology, molecular biology, histology and light microscopy.

Contact Information

Phone: 610-430-4601

List of Publications

• Pool, R., Turner, G.D., and S.A. Böttger. 2013. Recommended ecology content in introductory biology courses: comparisons between rural, suburban, and urban colleges. The American Biology Teacher, 75(8):544-9. S.A. Böttger, E.J. Amarosa, P. Geoghegan, C.W. Walker. 2013. Chronic Natural Occurrence of Disseminated Neoplasia in Select Populations of the Soft-shell Clam, Mya arenaria, in New England. Northeastern Naturalist 20(3): 430-40. N.G. Taraska, S.A. Böttger. 2013. Selective initiation and transmission of disseminated neoplasia in the soft shell clam Mya arenaria dependent on natural disease prevalence and animal size. Journal of Invertebrate Pathology 112: 94-101. E.E. Gestl, S.A. Böttger. 2012. Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines. Biochemical and Biophysical Research Communications 423(2): 411-6. S.A. Böttger, J.B. McClintock. 2012. Acetylcholine esterase activity and muscle contraction in the sea urchin Lytechinus variegatus (Lamarck) following chronic phosphate exposure. Environmental Toxicology 27(4):193-201. M.C. Pugliese, S.A. Böttger, F.E. Fish. 2012. Barnacle Bonding: Morphology of Attachment of Xenobalanus globicipitis to its host Tursiops truncatus. Journal of Morphology 273(4): 453-9. W.R. Fagerberg, J. Towle, C.R. Dawes, S.A. Böttger. 2012. Bioahdhesion in Caulerpa mexicana (Chlorophyta)
• Rhizoid-substrate adhesion. Journal of Phycology 48:264-269. C.W. Walker, B.E. Low, S.A. Böttger. 2012. Mortalin in invertebrates and the induction of apoptosis by wild-type p53 following defeat of mortalin-based cytoplasmic sequestration in cancerous clam hemocytes. Mortalin in Evolution – Mortalin in Invertebrates, S. Kaul, R. Wadhwa (editors). Springer Verlag. pg 97-113. S.A. Böttger, C.C. Eno, C.W. Walker. 2011. Methods for generating triploid green sea urchin embryos: An initial step in producing triploid adults for near-shore aquaculture. Aquaculture 318:199-206. C.W. Walker, R.J. Van Beneden, A. Muttray, S.A Böttger, M.L. Kelley, A.E. Tucker, W.K. Thomas. 2011. p53 Superfamily proteins marine bivalve Cancer and Stress Biology. M.P. Lesser (editor). Advances in Marine Biology, Vol. 59, pp 1-36. M.P. Lesser, K.L. Carlton, S.A. Böttger, T.M. Barry, C.W. Walker. 2011. Sea Urchin Tube Feet are Photosensory Organs that Express a Rhabdomeric-like Opsin and PAX6. Proceedings of the Royal Society of London 278(1723): 3371-9. C.C. Ginter, S.A. Böttger, F.E. Fish. 2011. Morphology and Microanatomy of Harbor Porpoise (Phocoena phocoena ) Dorsal Fin Tubercles. Journal of Morphology 272: 27-33. C.C. Eno, S.A. Böttger, C.W.Walker. 2009. Methods for karyotyping and for localization of developmentally relevant genes on the chromosomes of the purple sea urchin Strongylocentrotus purpuratus. Biological Bulletin 217: 306-12. Echinoderms: Durham, Proceedings of the 12th International Echinoderm Conference. 2009. L.G. Harris, S.A. Böttger, C.W. Walker, M.P. Lesser (Editors). CRC Press, Rotterdam, The Netherlands. pg.720. C.W. Walker, S.A. Böttger, J. Mulkern, E.C. Jerszyk, M. Litvaitis, M.P. Lesser. 2009. Mass Culture and Characterization of Tumor Cells from a Naturally Occurring Invertebrate Cancer Model: Applications for Human and Animal Disease and Environmental Health. Biological Bulletin 216: 23-39. S.A. Böttger and J.B. McClintock. 2009. The effects of chronic inorganic and organic phosphate exposure on bactericidal activity of the coelomic fluid of the sea urchin sea urchin Lytechinus variegatus (Echinodermata: Echinoidea). Comparative Biochemistry and Physiology, Part C 150: 39-44 C.W. Walker, S.A. Böttger. 2008. A Naturally Occurring Cancer with Molecular Connectivity to Human Diseases. Cell Cycle 7(15): 2286-89. S.A. Böttger, E.C. Jerszyk, Ben E. Low and C.W. Walker. 2008. Genotoxic Stress-Induced Expression of p53 and Restoration of Apoptosis in Leukemic Clam Hemocytes with Cytoplasmically Sequestered p53. Cancer Research 68: 777-82 S.A. Böttger, M.G. Devin and C.W. Walker. 2006. Suspension of gametogenesis in green sea urchins experiencing invariant photoperiod. Aquaculture 261: 1422-1431. Walker C.W., S.A. Böttger and B.E. Low. 2006. Mortalin-based cytoplasmic sequestration of p53 in a non-mammalian cancer model. American Journal of Pathology 168: 1526-30. S.A. Böttger, C.W. Walker and T. Unuma. 2004. Care and maintenance of adult echinoderms. In: Methods in Cell Biology, Volume 74, Development of sea urchins, ascidians and other invertebrate deuterostomes: Experimental approaches. C.E, Ettensohn, G.A. Wray and G.M. Wessel (Eds.) Elsevier Academic Press. pg.17-38. S.A. Böttger and J.B. McClintock. 2003. The effects of chronic inorganic and organic phosphate exposure on development and biochemical composition of the gonads in the sea urchin Lytechinus variegatus (Echinodermata: Echinoidea). In: Echinoderm Research 2001. J.P. Feral (ed.). Balkema, Rotterdam, pg. 265-268. S.A. Böttger, L.E. Thompson, S.A. Watts, J.B. McClintock and J.M. Lawrence. 2002. Episodic rainfall influences the distribution and abundance of the regular sea urchin Lytechinus variegatus in Saint Andrew Bay, northern Gulf of Mexico. Gulf of Mexico Science, 20(1): 67-74. S.A. Böttger and J.B. McClintock. 2002 The effects of inorganic and organic phosphate exposure on aspects of reproduction in the common sea urchin Lytechinus variegatus (Echinodermata: Echinoidea). Journal of Experimental Zoology, 292(7): 660-671. S.A. Böttger and J.B. McClintock. 2001. The effects of organic and inorganic phosphates on fertilization and early development of the sea urchin Lytechinus variegatus (Echinodermata: Echinoidea). Comparative Biochemistry and Physiology, C 129(4): 307-315. S.A. Böttger, J.B. McClintock and T.S. Klinger. 2001. Effects of inorganic and organic phosphates on feeding, feeding absorption, nutrient allocation and righting responses of the sea urchin Lytechinus variegatus. Marine Biology, 138(4): 741-751. Watts S.A., S.A. Böttger, J.B. McClintock and J.M. Lawrence. 1998. Gonad production in the sea urchin Lytechinus variegatus (Lamarck) fed prepared diets. Journal of Shellfish Research, 17(5):1591-1595. S.A. Böttger and T.S. Klinger. 1998. Responses of Arbacia punctulata (Echinodermata: Echinoidea) to stress induced by elevated phosphate levels. In: Echinoderms: San Francisco, R. Mooi and M. Telford (eds.). Balkema, Rotterdam, The Netherlands. pg 587-589.

Links

• ResearchGate